|
rs981058595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no difference in the I405V, C629A, and Taq1B polymorphisms between AD and control groups.
|
24468472 |
2014 |
|
rs769452
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs769450
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs769449
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
|
23562540 |
2013 |
|
rs769449
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
This study aims at examining the APOE promoter polymorphism rs769446 for possible association with AD in a Tunisian population.
|
26563666 |
2016 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms (SNPs) rs449647, rs769446 and rs405509 in the promoter region of the APOE gene have been variously suggested to be epsilon 4-independent risk factors for Alzheimer's disease (AD).
|
19172988 |
2009 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
The findings of this literature review and meta-analysis have shown that rs769446 polymorphism in the promoter region of <i>APOE</i> gene could be a risk factor for AD.
|
28900374 |
2017 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population.
|
29990559 |
2018 |
|
rs761592007
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Autosomal dominant Alzheimer's disease with early frontal lobe involvement associated with the Met239Ile mutation of Presenilin 2 gene.
|
22531416 |
2012 |
|
rs761592007
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.
|
10822446 |
2000 |
|
rs759721023
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This locus harbors a low-frequency coding variant (p.G215S, rs72973581, minor allele frequency = 4.3%) conferring a modest but statistically significant protection against AD (p-value = 0.024, odds ratio = 0.57, 95% confidence interval = 0.41-0.80).
|
27289440 |
2016 |
|
rs752600356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether M129V polymorphism is a risk factor for AD we analyzed a group of early-onset, and late-onset Polish AD patients.
|
16897605 |
2006 |
|
rs748703149
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a whole-exome sequencing study of a family with probable AD-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein E (APOE) ε4 allele, we identified an extremely rare TREM2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (NM_018965.3:c.433G>T/p.[Gly145Trp]).
|
31464095 |
2020 |
|
rs7412
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs7412
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease.
|
21215387 |
2011 |
|
rs7412
|
|
C |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs7412
|
|
|
0.720 |
GeneticVariation |
BEFREE |
APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease.
|
29776682 |
2018 |
|
rs7412
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs7259620
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs7259620
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
|
23565137 |
2013 |
|
rs533904656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses on AD association with BACE1 exon 5, BACE1 intron 5, FE65 intron 13, CYP46 intron 2, alpha(1)-antichymotrypsine Ala17Thr, bleomycin hydrolase I443V, lectin-like oxidized low-density lipoprotein receptor (OLR1) 3'-UTR (+1071) and (+1073), and very-low-density lipoprotein receptor (VLDLR) 5'-UTR (CGG-repeat) polymorphisms.
|
17854420 |
2008 |
|
rs449647
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Therefore this study confirms the role of the rs449647 A/A genotype as risk factor for AD in Italy and suggests that promoter genotypes and APOE haplotypes might have a complex function in AD-associated genetic risk factors.
|
19172988 |
2009 |
|
rs449647
|
|
|
0.730 |
GeneticVariation |
BEFREE |
A total of 23 publications (19 for rs449647, ten for rs769446 and ten for rs405509) were retrieved that included 5,703 patients with AD and 5,692 controls.
|
28900374 |
2017 |